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Page 1
Benzothiazolyl and Benzoxazolyl Hydrazones Function as Zinc Metallochaperones to Reactivate Mutant p53.
J Med Chem. 2021 Feb 25;64(4):2024-2045. doi: 10.1021/acs.jmedchem.0c01360. Epub 2021 Feb 4.
J Med Chem. 2021.
PMID: 33538587
Free PMC article.
Combinatorial Therapy of Zinc Metallochaperones with Mutant p53 Reactivation and Diminished Copper Binding.
Zaman S, Yu X, Bencivenga AF, Blanden AR, Liu Y, Withers T, Na B, Blayney AJ, Gilleran J, Boothman DA, Loh SN, Kimball SD, Carpizo DR.
Zaman S, et al. Among authors: blayney aj.
Mol Cancer Ther. 2019 Aug;18(8):1355-1365. doi: 10.1158/1535-7163.MCT-18-1080. Epub 2019 Jun 13.
Mol Cancer Ther. 2019.
PMID: 31196889
Free PMC article.
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Zinc shapes the folding landscape of p53 and establishes a pathway for reactivating structurally diverse cancer mutants.
Blanden AR, Yu X, Blayney AJ, Demas C, Ha JH, Liu Y, Withers T, Carpizo DR, Loh SN.
Blanden AR, et al. Among authors: blayney aj.
Elife. 2020 Dec 2;9:e61487. doi: 10.7554/eLife.61487.
Elife. 2020.
PMID: 33263541
Free PMC article.
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